Tricaprilin is an investigational drug containing a highly purified form of medium chain triglyceride (MCT). MCTs are a specific type of oil found in coconut and palm kernel and foods, such as goat’s milk.
Ketogenic diets (KD) have been used by many people for many reasons and some people with migraine have reported benefits, though the efficacy and safety of the KD have not been proven for migraine. The KD is also very restrictive and therefore difficult to maintain. MCTs such as tricaprilin also raise ketone levels, without the need for restricting food intake.
The Tricaprilin Relief study in migraine is based on a growing body of scientific evidence suggesting ketone bodies may help reduce the frequency of and prevent migraine attacks. The exact way this happens is not yet clear, but could be due to addressing deficient brain glucose metabolism that is characteristic of numerous neurological conditions.
The ketogenic diet was designed by physicians in the 1920’s to help control seizures in children with epilepsy by mimicking a fasting metabolism. During the past two decades, interest in the ketogenic diet has increased dramatically. There is now some, although limited, evidence showing a ketogenic diet may reduce migraine attacks . The ketogenic diet shifts metabolism from burning carbohydrates to burning ketones for fuel; however, it is often difficult to maintain such a highly restrictive diet over a prolonged period of time.